Fig. 5
From: Loss of the molecular clock in myeloid cells exacerbates T cell-mediated CNS autoimmune disease
Dysregulation of Bmal1 and Reverba during the acute disease phase of EAE. a–c Spinal cords were removed from 14 d myelin oligodendrocyte glycoprotein (MOG35–55), complete Freund’s adjuvant (CFA) and pertussis toxin (PT)-immunized or naive female C57BL/6 mice. a, b RT-PCR analysis of isolated spinal cords (n = 4–6). c Linear regression of clinical scores of 10 mice vs. Bmal1 gene expression in the same animals (n = 10). Statistics were performed by Mann–Whitney U test (a–c). All data presented as means±standard error of the mean (SEM). RQ relative quantification.*p < 0.05; **p < 0.01
