Fig. 5 | Nature Communications

Fig. 5

From: Input-dependent regulation of excitability controls dendritic maturation in somatosensory thalamocortical neurons

Fig. 5The alternative text for this image may have been generated using AI.

Overexpression of Kv1.1 enables normal dendritic development of Grin1KOThEpor and VPMIONS neurons. a Kcna1 electroporation enables dendritic development in Grin1KOThEpor neurons (P7 Grin1KOThEpor + Kcna1GFP n = 15 from 6 mice). P7 WT and P7 Grin1KOThEpor data reported from Fig. 1b and d. Scale bar: 20 μm. b Kcna1 overexpression enables the dendritic development of VPMIONS neurons (P7 IONS + Kcna1GFP n = 14 from 7 mice). P7 WT and P7 IONS data reported from Figs. 1b and 4c. Scale bar: 20 μm. c Left: linear model integrating the dendritic complexity parameters described above, using control P2 and P7 conditions as training data sets. Right: summary of the findings. One-way ANOVA with Tukey's post-hoc test for all statistical tests relating to dendritic complexity, except for Sholl analyses for which a two-way ANOVA with Tukey's post-hoc test was used. *P < 0.05, **P < 0.01, ***P < 0.001

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