Table 1 Cis-acting SNP association results for 34 proteins with significant pQTL signal at baseline
From: Protein quantitative trait locus study in obesity during weight-loss identifies a leptin regulator
PROTEIN | SNP | Chr | Position | MA | MAF | Coef | SE | p value | Adjusted p value |
|---|---|---|---|---|---|---|---|---|---|
IL-1 R AcP | rs6444444 | 3 | 190346231 | A | 0.16 | 0.66 | 0.039 | 4.60 × 10−66 | 1.05 × 10−69 |
SAA | rs7950019 | 11 | 18278912 | G | 0.37 | 1.53 | 0.109 | 4.81 × 10−45 | 2.52 × 10−44 |
IL-16 | rs4778636 | 15 | 81591639 | A | 0.07 | −0.48 | 0.039 | 1.00 × 10−35 | 7.68 × 10−37 |
MIA | rs2607426 | 19 | 41274713 | G | 0.06 | 0.49 | 0.04 | 3.95 × 10−34 | 8.55 × 10−36 |
HCC-4 | rs11080369 | 17 | 34305164 | C | 0.05 | −0.79 | 0.069 | 1.58 × 10−30 | 6.97 × 10−31 |
kallikrein 12 | rs3745540 | 19 | 51535130 | A | 0.38 | 0.33 | 0.029 | 8.36 × 10−29 | 4.54 × 10−28 |
sICAM-5 | rs281440 | 19 | 10400304 | G | 0.24 | −0.3 | 0.028 | 6.75 × 10−27 | 1.95 × 10−27 |
NPS-PLA2 | rs10732279 | 1 | 20305065 | C | 0.27 | 0.38 | 0.036 | 3.44 × 10−26 | 5.76 × 10−27 |
ATS13 | rs4962144 | 9 | 136275141 | A | 0.1 | −0.34 | 0.035 | 7.08 × 10−23 | 1.84 × 10−22 |
ECM1 | rs13294 | 1 | 150484987 | A | 0.44 | −0.2 | 0.02 | 6.65 × 10−22 | 4.38 × 10−22 |
PARC | rs972317 | 17 | 34371659 | G | 0.12 | 0.5 | 0.052 | 6.90 × 10−22 | 4.61 × 10−23 |
Carbonic anhydrase 6 | rs3765964 | 1 | 9034421 | A | 0.39 | 0.44 | 0.052 | 3.37 × 10−17 | 3.20 × 10−17 |
Factor H | rs1329428 | 1 | 196702810 | T | 0.43 | 0.08 | 0.009 | 4.94 × 10−16 | 1.22 × 10−16 |
TECK | rs11671930 | 19 | 8117308 | C | 0.16 | −0.5 | 0.063 | 1.38 × 10−15 | 1.23 × 10−15 |
Haptoglobin mixed type | rs2000999 | 16 | 72108093 | A | 0.2 | −0.49 | 0.062 | 3.23 × 10−15 | 2.56 × 10−16 |
FCN2 | rs7851696 | 9 | 137779091 | T | 0.11 | −0.38 | 0.049 | 4.61 × 10−15 | 1.07 × 10−15 |
Kallistatin | rs5510 | 14 | 95033356 | T | 0.24 | 0.11 | 0.014 | 8.78 × 10−14 | 2.27 × 10−15 |
Cripto | rs3806702 | 3 | 46617502 | C | 0.27 | 0.14 | 0.019 | 9.53 × 10−14 | 2.57 × 10−13 |
CYTN | rs6036507 | 20 | 23721992 | A | 0.3 | 0.31 | 0.042 | 2.25 × 10−13 | 2.04 × 10−13 |
WFKN2 | rs4586493 | 17 | 48924465 | A | 0.28 | 0.18 | 0.026 | 7.84 × 10−12 | 3.25 × 10−12 |
CYTT | rs6036507 | 20 | 23721992 | A | 0.3 | 0.3 | 0.045 | 1.02 × 10−11 | 2.04 × 10−13 |
Contactin-5 | rs1461674 | 11 | 99180043 | T | 0.08 | 0.23 | 0.035 | 1.18 × 10−11 | 3.21 × 10−12 |
MIP-1a | rs972317 | 17 | 34371659 | G | 0.12 | 0.35 | 0.051 | 1.33 × 10−11 | 4.61 × 10−23 |
Factor B | rs541862 | 6 | 31916951 | C | 0.08 | 0.15 | 0.023 | 3.39 × 10−11 | 6.73 × 10−12 |
Proteinase-3 | rs2074639 | 19 | 840984 | T | 0.22 | 0.22 | 0.033 | 5.74 × 10−11 | 1.39 × 10−10 |
TIG2 | rs10282458 | 7 | 150045302 | A | 0.25 | 0.12 | 0.018 | 2.11 × 10−10 | 1.34 × 10−9 |
LD78-beta | rs972317 | 17 | 34371659 | G | 0.12 | 0.2 | 0.032 | 3.27 × 10−10 | 4.61 × 10−23 |
TSG-6 | rs6715902 | 2 | 152201469 | A | 0.34 | 0.18 | 0.031 | 3.23 × 10−9 | 8.92 × 10−9 |
LBP | rs2284878 | 20 | 36785127 | A | 0.06 | −0.36 | 0.062 | 4.07 × 10−9 | 5.92 × 10−9 |
C7 | rs3805221 | 5 | 40965318 | T | 0.24 | −0.12 | 0.02 | 6.73 × 10−9 | 7.45 × 10−9 |
Factor I | rs7439493 | 4 | 110656730 | A | 0.42 | 0.06 | 0.01 | 1.46 × 10−8 | 4.69 × 10−9 |
Kallikrein 7 | rs1654523 | 19 | 51485194 | C | 0.08 | −0.24 | 0.044 | 5.57 × 10−8 | 1.75 × 10−8 |
TSP2 | rs3763267 | 6 | 169571693 | C | 0.09 | 0.29 | 0.053 | 5.66 × 10−8 | 5.20 × 10−8 |
CHL1 | rs6769747 | 3 | 244949 | G | 0.1 | 0.16 | 0.03 | 1.37 × 10−7 | 6.81 × 10−6 |
