Table 2 Trans-acting SNP association results for 22 proteins with significant pQTL signal at baseline
From: Protein quantitative trait locus study in obesity during weight-loss identifies a leptin regulator
Protein | SNP | Chr | Position | MA | MAF | Coef | SE | p value | Adjusted p value |
|---|---|---|---|---|---|---|---|---|---|
sE-Selectin | rs495828 | 9 | 136154867 | T | 0.2 | −0.5 | 0.04 | 8.98 × 10−40 | 1.13 × 10−39 |
Calpastatin | rs11599750 | 10 | 101805442 | T | 0.4 | −0.2 | 0.02 | 3.78 × 10−12 | 2.49 × 10−12 |
FCN2 | rs7103402 | 11 | 114391633 | T | 0.1 | −0.3 | 0.05 | 7.27 × 10−11 | 1.69 × 10−10 |
MP2K2 | rs12876365 | 13 | 113911651 | T | 0.2 | −0.2 | 0.03 | 3.37 × 10−10 | 1.27 × 10−10 |
HAI-1 | rs1886748 | 1 | 39333775 | A | 0.4 | −0.2 | 0.03 | 6.97 × 10−10 | 5.62 × 10−10 |
IDS | rs7661253 | 4 | 183039092 | C | 0.4 | −0.2 | 0.03 | 1.50 × 10−9 | 3.68 × 10−9 |
CATZ | rs10860794 | 12 | 102217720 | A | 0.3 | −0.1 | 0.02 | 1.78 × 10−9 | 7.39 × 10−9 |
40 S ribosomal protein SA | rs7299019 | 12 | 105271085 | T | 0.1 | 0.27 | 0.05 | 1.56 × 10−8 | 7.98 × 10−9 |
PUR8 | rs10513494 | 3 | 156291263 | G | 0.1 | 0.42 | 0.08 | 2.74 × 10−8 | 6.52 × 10−8 |
a1-Antichymotrypsin | rs10509957 | 10 | 114053983 | A | 0.4 | −0.1 | 0.01 | 3.80 × 10−8 | 2.46 × 10−7 |
Carbonic anhydrase I | rs10513494 | 3 | 156291263 | G | 0.1 | 0.42 | 0.08 | 3.93 × 10−8 | 1.13 × 10−7 |
TGF-b3 | rs2058950 | 7 | 155182326 | A | 0.2 | 0.1 | 0.02 | 7.13 × 10−8 | 1.05 × 10−7 |
IL-7 | rs7836269 | 8 | 13748948 | G | 0.1 | 0.31 | 0.06 | 7.66 × 10−8 | 1.90 × 10−7 |
Cytochrome c | rs9325542 | 10 | 114977369 | G | 0.2 | 0.15 | 0.03 | 7.86 × 10−8 | 2.45 × 10−7 |
ACTH | rs2268992 | 6 | 88183647 | G | 0.1 | 0.35 | 0.07 | 9.18 × 10−8 | 2.27 × 10−8 |
MMP-16 | rs11230085 | 11 | 59578322 | A | 0.1 | 0.23 | 0.04 | 9.68 × 10−8 | 1.25 × 10−7 |
Nectin-like protein 1 | rs12420752 | 11 | 21866461 | T | 0.1 | 0.31 | 0.06 | 1.18 × 10−7 | 2.27 × 10−7 |
BGN | rs7309378 | 12 | 12828528 | A | 0.1 | −0.2 | 0.04 | 1.24 × 10−7 | 7.15 × 10−7 |
Coactosin-like protein | rs10908893 | 9 | 92117102 | T | 0 | 0.32 | 0.06 | 1.27 × 10−7 | 2.53 × 10−8 |
NKp44 | rs1432180 | 2 | 82079857 | A | 0.2 | 0.11 | 0.02 | 1.51 × 10−7 | 2.67 × 10−7 |
MMP-2 | rs7935013 | 11 | 467339 | G | 0.3 | 0.09 | 0.02 | 1.52 × 10−7 | 8.29 × 10−7 |
Ferritin | rs12485954 | 3 | 156336114 | C | 0.1 | 0.47 | 0.09 | 1.54 × 10−7 | 3.40 × 10−7 |
