Table 3 Functional annotation of 102 cis and 45 trans-pQTL associated to proteins level at baseline

From: Protein quantitative trait locus study in obesity during weight-loss identifies a leptin regulator

Function

Cis regulation

Trans regulation

 

Count

Proportion

Corrected p value

Count

Proportion

Corrected p value

3′downstream

0

0

1

1

0.022

1

5′upstream

9

0.088

0.00061

4

0.089

0.057

5′utr

1

0.01

1

1

0.022

0.5

coding

10

0.098

0.00022

1

0.022

1

intergenic

30

0.294

1

16

0.356

1

intronic

51

0.5

1

22

0.489

1

non-coding intronic

1

0.01

0.22

0

0

1

  1. p value from two-tailed Fisher’s exact test for enrichment analysis of pQTL SNPs among regulatory elements were adjusted for multiple testing using Bonferroni correction
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