Table 5 Substrate scope for asymmetric reaction

From: Radical asymmetric intramolecular α-cyclopropanation of aldehydes towards bicyclo[3.1.0]hexanes containing vicinal all-carbon quaternary stereocenters

  1. Conditions A: CuI (20 mol%), L1 (10 mol%), A12 (20 mol%), F-BI-OH (2 equiv.), MeCN (0.1 M), 20 °C, 48 h; Conditions B: CuI (20 mol%), L1 (10 mol%), A12 (20 mol%), DF-BI-OH (2 equiv.), n-Bu4NI (20 mol%), MeCN (0.1 M), 10 °C, 72 h; Conditions C: CuI (20 mol%), L1 (10 mol%), A14 (20 mol%), DF-BI-OH (2 equiv.), n-Bu4NI (20 mol%), MeCN (0.1 M), 10 °C, 72 h; Er was determined by chiral stationary HPLC; the isolated yield was shown
  2. * CuI (30 mol%), L1 (15 mol%), A14 (25 mol%), DF-BI-OH (2 equiv.), n-Bu4NI (25 mol%), MeCN (0.1 M), 20 °C, 48 h
  3. CuI (30 mol%), L4 (15 mol%), A14 (25 mol%), DF-BI-OH (2 equiv.), n-Bu4NI (25 mol%), MeCN (0.1 M), 10 °C, 72 h
  4. †Reaction was run at 20 °C for 62 h
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