Fig. 1
From: Hepatitis B virus persistence in mice reveals IL-21 and IL-33 as regulators of viral clearance
BPS persistence in BALB/c mice. Sera from BPS, B200 or B6 HDI mice were analysed for HBsAg (a), HBeAg (b), HBV DNA (c) and ALT (d). Group means and s.e.m. within group are presented with group sizes (n) indicated. Group positivity percentage data are also plotted for HBsAg (a, right panel) and HBeAg (b, right panel). Dotted lines represent cut-off thresholds (a, b, left panels), lower limit of quantification (c) or pre-injection baseline (d), respectively. B6 and B200 data are compared against BPS and statistical significance calculated using log-rank (Mantel–Cox) test (a, b, right panels) or unpaired two-tailed t-test (c, d). *p < 0.05; **p < 0.01; ***p < 0.001. e Liver sections taken from control and serum HBsAg positive BPS HDI mice were stained for HBsAg (arrow heads) in addition to H&E staining. Representative images from 2 mice are shown. w.p.i. weeks post injection. geq genome equivalents. Scale bars: 50 μm
