Fig. 1
From: DNA methylation signatures of illicit drug injection and hepatitis C are associated with HIV frailty
Epigenome-wide association analysis identifies six significant CpG sites for injection of illicit drug use comorbid with hepatitis C in HIV-infected individuals. a Manhattan plot of chromosomal locations of −log10(p values) for association in 437,722 CpG sites among 386 HIV-infected African American men with and without injection of illicit drugs comorbid with hepatitis C infection in the discovery sample set. The red line presents the threshold for nominal p = 5E10-07. b Violin plot showing differential DNA methylation of six significant CpG sites between subjects comorbid for injection drug use and hepatitis C (IDU+/HCV+) compared to non-injection drug use and non-hepatitis C (IDU−/HCV−) subjects in the discovery sample. Methylation (β) is on a scale 0–1. The line in the middle shows average methylation in each group. Four CpG sites (cg07839457, cg10439456, cg0539368, cg22107533,) were hypomethylated and two CpG sites (cg22917487 and cg05349042) were hypermethylated in IDU+/HCV+ compared to IDU−/HCV−
