Table 1 Demographic and clinical characterizations

From: DNA methylation signatures of illicit drug injection and hepatitis C are associated with HIV frailty

 

Discovery sample

Replication sample

 

IDU+/HCV+ (N = 216)

IDU−/HCV− (N = 170)

IDU+/HCV+ (N = 104)

IDU−/HCV− (N = 308)

Age (year)

51.38 ± 4.80

47.04 ± 9.04a

49.91 ± 5.00

47.22 ± 8.47a

Sex (male, %)

100

100

100

100

Race (AA, %)

100

100

100

100

HIV-infection (%)

100

100

100

100

Smoker (%)

70.4

47.6a

67.3

49.7a

Alcohol (AUDIT-C)

4.72 ± 3.73

3.01 ± 2.99

3.75 ± 3.30

3.09 ± 2.75

ART adherence (%)

74.5

75.9

74

77

Log 10 HIV-1 load

2.61 ± 1.11

2.81 ± 1.34

2.63 ± 1.10

2.68 ± 1.26

CD4+ T (cell count)

404 ± 262

448 ± 286

441 ± 272

459 ± 290

CD8+ T (%)

0.18 ± 0.08

0.18 ± 0.08

0.16 ± 0.07

0.16 ± 0.08

NK (%)b

0.07 ± 0.06

0.09 ± 0.06

0.08 ± 0.06

0.08 ± 0.05

B cell (%)b

0.09 ± 0.05

0.08 ± 0.04

0.12 ± 0.05

0.11 ± 0.05

Monocyte (%)b

0.12 ± 0.04

0.12 ± 0.04

0.11 ± 0.04

0.10 ± 0.04

Granulocyte (%)b

0.51 ± 0.13

0.53 ± 0.14

0.50 ± 0.11

0.51 ± 0.11

  1. AA African American, ART antiretroviral therapy, AUDIT-C, Alcohol Use Disorders Identification Test
  2. aIDU+/HCV+ versus IDU−/HCV− p<0.001
  3. bMethylation estimated cell type compositions
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