Fig. 6
From: The evolutionary landscape of chronic lymphocytic leukemia treated with ibrutinib targeted therapy
Disease progression without BTK or PLCG2 mutations. As in Fig. 5, detailed information is presented for two cases in which WES revealed no PLCG2 or BTK mutations. Top panel shows the absolute lymphocyte count (ALC) over the patient’s clinical course, as well as changes in CCF of subclones as depicted in the inferred phylogenetic tree. Bottom panel shows the inferred growth kinetics of the different subclones, including measurements with corresponding CI, as well as the exponential growth curves with CI as shaded area. The calculated growth or decline rates from the exponential growth curves as well as the corresponding R 2 fit with exponential growth dynamics is listed in the table in the bottom panel. *We note that R 2 = 1.0 merely reflects that only two data points were available for fitting
