Fig. 2

Imipenem and meropenem intermediates bound to the active site of NDM-1. a–e Stereo views of the Δ² isomer of hydrolyzed imipenem (a), or meropenem (d), in EI₁, the Δ¹ isomer of hydrolyzed imipenem (b), or meropenem (e), in EI₂, and the Δ¹ isomer of hydrolyzed imipenem in EP (c), represented as ball-and-stick models. The 2F _o – F _c electron density shown as gray mesh is contoured at 1.0 σ and the omit F _o – F _c electron density shown as green mesh is contoured at 3.0 σ. f Overlay of hydrolyzed imipenem in EI₁ and EI₂. g Overlay of hydrolyzed imipenem and meropenem in EI₁. Zinc ions are represented by magenta spheres in all panels