Fig. 2 | Nature Communications

Fig. 2

From: Hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation

Fig. 2

The mouse model of simulated menstruation reveals physiological hypoxia at menses. a Murine model of simulated menstruation. E2 estradiol, P4 progesterone, Ovex ovariectomy. T0 time of P4 implant removal, T8 8 h following progesterone withdrawal, T24 24 h following P4 withdrawal. b Representative endometrial pimonidazole staining from two mice T0, T8 and T24 (inset = negative control). Total replicates T0 (n = 4), T8 (n = 7) and T24 (n = 11). DM decidualised mass, E endometrium, M myometrium, SE surface epithelium. Arrow indicates positive staining in endometrium that has not yet reepithelialised. Scale bar = 100 μm

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