Fig. 4 | Nature Communications

Fig. 4

From: Hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation

Fig. 4

HIF-1α heterozygote mice display delayed endometrial repair following progesterone withdrawal. a Endometrial histological breakdown/repair score at 8 h following P withdrawal (T8) and b at 24 h following P withdrawal (T24) in HIF-1α heterozygote (HET, HIF-1α+/−) versus wild type (WT, HIF-1α+/+ mice. Graphs represent percentage of mice at each histological grade per experimental group. *P < 0.05, unpaired t-test. c Relative mRNA concentration of Vegf and Cxcr4 in uterine tissue from HET versus WT mice at T0 (n = 2/4), T8 (n = 5/7) and T24 (n = 11/11). Box represents upper and lower quartiles with horizontal line representing the median, whiskers represent minimum and maximum values. d Carbonic anhydrase IX immunohistochemical staining in HIF-1α heterozygote (HET) and wild-type (WT) mice. Arrows represent area of endometrial separation. M myometrium, E endometrium, DM decidualised mass. Inset = negative control. Scale bar = 100 μm

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