Table 1 Association of rs13390936 with NTS bacteraemia in African children

From: Risk of nontyphoidal Salmonella bacteraemia in African children is modified by STAT4

Population

Case

Control

Genotypic model

 

Recessive model

 

Freq.

TT/AT/AA

Freq.

TT/AT/AA

P value

P value

OR (95% CI)

 Kenya (discovery)

0.151

8/40/138

0.107

15/529/2068

1.76 × 10–5

3.33 × 10–6

8.03 (3.34–19.31)

 Kenya (replication)

0.146

3/4/30

0.106

12/254/1053

1.83 × 10–3

6.54 × 10–4

9.96 (2.66–37.36)*

 Malawi

0.15

6/31/106

0.136

3/86/249

0.039

0.026

4.89 (1.21–19.83)*

 Combined

     

8.62 × 10–10

7.61 (3.98–14.55)

  1. rs13390936 is directly genotyped in all samples by HRMA. Freq. minor allele frequency, OR odds ratio, CI confidence interval, HRMA high-resolution melting curve analysis
  2. *Fisher's exact estimates of effect sizes in the Kenyan (OR = 9.56, P = 6.79 × 10–3) and Malawian (OR = 4.87, P = 0.023) replication samples (without covariates) are comparable to those derived by logistic regression
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