Fig. 3 | Nature Communications

Fig. 3

From: The podoplanin-CLEC-2 axis inhibits inflammation in sepsis

Fig. 3

CLEC-2 protective effect is not mediated by podoplanin expressed on podocytes. Glomeruli on frozen kidney sections from PDPNfl/fl mice and PDPNfl/flPodocin-cre+ stained for podoplanin from a unchallenged and b LPS-treated mice (n = 6). Scale bar = 20 μm. Arrow indicates podoplanin staining on parietal epithelial cells and star indicates the absence of podoplanin on the podocytes. c Platelet count (n = 8), d white blood cell (WBC) count (n = 8), e blood albumin (≥7 mice) and f BUN levels in mice before (open symbol) (≥7 mice) and 8 h post LPS (closed symbol). Data are means ± s.d. Differences analyzed by one-way ANOVA with Tukey’s multiple comparison tests. ***p < 0.001, ****p < 0.0001

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