Fig. 3
From: Desumoylase SENP6 maintains osteochondroprogenitor homeostasis by suppressing the p53 pathway
Senp6 loss delayed DNA damage repair. a Dermo1-Cre;Senp6f/f mice (E18.5) had more γH2AX-positive cells in the growth plate RZ, PZ, perichondrium, and periosteum than did Senp6f/f controls; scale bars = 100 μm for the growth plate (left) and 50 μm for the rest. b Dermo1-Cre;Senp6f/f mice showed an increased basal level of γH2AX foci (non-irradiated), higher sensitivity to irradiation (at 10 min), and lower clearance of γH2AX foci during recovery at 30 min to 24 h (n = 3; 50 areas of each slide were quantified, error bars = standard deviation, *p < 0.05, relative to control, Student’s t-test); scale bars = 10 μm
