Fig. 8 | Nature Communications

Fig. 8

From: The peroxisomal AAA-ATPase Pex1/Pex6 unfolds substrates by processive threading

Fig. 8

Model for Pex1/Pex6 activity at the peroxisomal membrane. Pex1/Pex6 is recruited to the peroxisomal membrane by binding to Pex15, which mediates its interaction with Pex5, Pex14, and potentially other Pex proteins (gray). Pex1/Pex6 ATPase activity at the peroxisome membrane leads to unfolding of one or more members of this complex, which either directly or indirectly causes Pex5 extraction from the peroxisomal membrane

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