Fig. 6
Chronotherapeutic effects of d-allulose (1 g kg−1 day−1) on hyperphagic obesity in HFD-fed mice. Subchronic treatment for 9 days of HFD-fed obese C57BL/6J mice with 1 g kg−1 day−1 p.o. Allu once daily at LP 7:30. a–c HFD-fed mice (HFD-fed), compared to C57BL/6J lean mice fed standard chow (Chow-fed), exhibited LP-selective hyperphagia accompanied by daily hyperphagia. Subchronic administration of Allu significantly suppressed LP (a, c), but not DP (b, c), and daily food intake (c), tended to attenuate body weight gain (d), and significantly decreased visceral WAT weight (e) and triacylglycerol content in liver (f). Visceral WAT weight was the sum of mesenteric, perirenal, and epididymal WAT. n = 5–6. In a, b, d, different letters p < 0.05 by two-way ANOVA followed by Tukey’s test. In c, e, f, *p < 0.05, and **p < 0.01 by one-way ANOVA followed by Tukey’s test. Error bars are SEM
