Fig. 1 | Nature Communications

Fig. 1

From: A biosensor-based framework to measure latent proteostasis capacity

Fig. 1

Design strategy for probing proteostasis efficiency. Scheme of how the bait biosensor module measures collective cellular chaperone engagement by binding to unfolded barnase and in preventing aggregation. Medium FRET and low FRET: binding of quality control machinery to barnase bait pulls the equilibrium away from folded barnase, reducing the FRET signal in the soluble pool. High FRET: quality control systems reduce aggregate accumulation, thereby reducing the number of cells with high-FRET

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