Fig. 1
From: Integrative genomic and transcriptomic analysis of leiomyosarcoma
Mutational landscape of adult LMS. a Frequency and type of mutations. Rows represent individual genes, columns represent individual tumors. Genes are sorted according to frequency of SNVs/indels (left). Asterisks indicate significantly mutated genes according to MutSigCV. Bars depict the number of SNVs/indels for individual tumors (top) and genes (right). Established cancer genes are shown in bold. Types of mutations and selected clinical features are annotated according to the color codes (bottom). b Schematic representation of SNVs/indels in TP53, RB1, and ATRX. Protein domains are indicated (Trans transactivation domain, SH3 Src homology 3-like domain, Tetra tetramerization domain, DUF3452 domain of unknown function, RB_A RB1-associated protein domain A, RB_B RB1-associated protein domain B, RB_C RB1-associated protein domain C, EZH2-ID EZH2 interaction domain, SNF2 N ter SNF2 family N-terminal domain, Hel helicase domain). c Top subnetworks from HotNet2 analysis of genes harboring SNVs/indels. MutSigCV P-values (−log10) for individual genes are annotated according to the color code
