Fig. 4
From: Integrative genomic and transcriptomic analysis of leiomyosarcoma
Genetic lesions targeting TP53 and RB1 in adult LMS. a Structural variant plots of all fusion transcripts involving TP53 and RB1 detected in 37 tumors. b Interchromosomal rearrangement resulting in a non-functional TP53-TCERG1 fusion transcript in case LMS44 (top) and intrachromosomal rearrangement resulting in a non-functional RB1-ATP8A2 fusion transcript in case LMS45 (bottom). TS transcriptome sequencing, chr chromosome. c Schematic representation of different genetic lesions targeting TP53 and RB1. e exon, i intron, chr chromosome, UTR untranslated region
