Fig. 1 | Nature Communications

Fig. 1

From: DNA methyltransferase inhibition upregulates MHC-I to potentiate cytotoxic T lymphocyte responses in breast cancer

Fig. 1

DMTi treatment augments MHC-I and MHC-II expression of human breast cancer samples. a Correlation matrix of methylation status and mRNA expression of MHC-I (HLA-A/B/C), MHC-II (HLA-DRA), and PD-L1 (CD274) from TCGA breast cancer patient data. Pearson’s correlation coefficients are shown in box. b Geometric mean fluorescence intensity (GMFI) ratio of MHC-I and MHC-II in multiple subtypes of human breast cancer cell lines (ER+/MCF7; HER2+/BT474; Claudin-low/BT549; TNBC/HCC1395) under guadecitabine (DMTi) treatment + IFNγ stimulation. GMFI ratio of diluent group was used as the baseline. *p < 0.05; **p < 0.01; ****p < 0.0001 (one-way ANOVA with Tukey’s multiple comparisons correction to compare individual groups). All data are means ± SEM. Each dot represents one independent experimental result. c Viability assay of multiple subtypes of human breast cancer cell lines (ER+/MCF7; HER2+/BT474; Claudin-low/BT549; TNBC/HCC1395) under DMTi treatment. All data are means ± SD

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