Fig. 6

In vivo photothermal activation of TRPV1 reduces atherosclerotic lesions in ApoE⁻/⁻ mice on a high-fat diet. a NIR laser treatment. b Representative images of Oil Red O-stained aortic root sections. Haematoxylin was used as a counterstain. Scale bar = 250 μm. c Representative images of Oil Red O-stained en face aortic preparations. Within the dashed box above is the aortic arch and below it is the thoracic-abdominal aorta. d–f Quantification of Oil Red O-stained area. Data are shown as mean ± S.D. (n = 10), and analyzed by Student’s t-test. ^**P < 0.01 for CuS-TRPV1 + Laser vs. PBS, ^#P < 0.05 for Cap vs. PBS, ^&P < 0.05 for CuS-TRPV1 + Laser vs. Cap