Fig. 4
Identification of synovial fibroblast subtypes. a Bulk expression (‘in silico average’) comparison of fibroblast populations (1 vs. 2a&b combined across all patients). Genes up-regulated in fibroblast population 1, based on differential expression analysis with Bonferroni-corrected p < 0.05, are indicated in red and genes expressed predominantly in fibroblast population 2 are indicated in teal. b Expression comparison across fibroblast sub-populations 2a and 2b. c CD55 (top) and THY1 (CD90) (bottom) expression across the global tSNE. d Pathway and gene set overdispersion analysis on the three fibroblast populations identified from unbiased clustering of single cell RNA-seq data from patient RABP3. Enrichment score corresponds to each cells’ first principle component loading from pathway analysis as computed in pagoda
