Fig. 8
From: Lack of beta-arrestin signaling in the absence of active G proteins
Ligand-stimulated pERK1/2 profiles in wild-type HEK293 and Δβarr1/2 cells. Kinetic pERK1/2 profiles of agonist-stimulated DP2 (a–d), M3D-WT (e–h), AT1R (i–l), β2AR (m–p), V2R (q–t), and GPCR-independent MAPK pathway activation by EGF (u–x) in wild-type (WT) (a, e, i, m, q, u), wild-type (WT) (parental) (b, f, j, n, r, v), Δβarr1/2 clone #2 (c, g, k, o, s, w), or Δβarr1/2 clone #3 (d, h, l, p, t, x). Data are mean ± s.e.m. of three independent experiments (three technical replicates)
