Table 2 Enantioselective reductive cross-coupling of nitrones with aldehydesa

From: Dual catalysis for enantioselective convergent synthesis of enantiopure vicinal amino alcohols

 
  1. a General method: Ru(bpy)3(PF6)2 (2.0 mol%), Sc(OTf)3 (15 mol%), L1-b (18 mol%), DCE (c 0.05 M), 65 W CFL, 0 °C, 48 h
  2. b Isolated yield
  3. c dr values (anti/syn) were detected from 1H NMR or chiral HPLC analysis of crude products
  4. d ee values were detected from chiral HPLC analysis
  5. e DCM was used as solvent
  6. f Modified method 1: Ru(bpy)3(PF6)2 (2.0 mol%), Sc(OTf)3 (15 mol%), L1-a (18 mol%), DIPEA (4.0 eq), DCM (c 0.05 M), 65 W CFL, −5 °C, 48 h
  7. g Modified method 2: Ru(bpy)3(PF6)2 (2.0 mol%), La(OTf)3 (15 mol%), L2-b (30 mol%), TEEDA (4.0 eq), CH3CN (c 0.05 M), 65 W CFL, −10 °C, 72 h
Back to article page