Fig. 8
Inhibition of LD production promotes tumour regression. a Twelve-week-old female balb/c mice (n = 32) bearing CT26-Ctl or CT26-lpcat2 tumours were subdivided into four groups (n = 8 per group) and intraperitoneally injected with triacsin C (2 mg/kg) once a week for 3 weeks followed the next day by FOX, or with FOX and triacsin C alone or with vehicles alone (NT groups). Tumour size in mm2 over time is represented as median ± s.e.m. P values were determined by two-way ANOVA with Bonferroni correction. *p < 0.05, **p < 0.01, ***p < 0.001. b Kaplan–Meier plots with time of death as endpoint for mice described in a are presented with p values assessed by a log-rank test. c Twelve-week-old female NMRI-nude mice (n = 32) bearing CT26-Ctl (left panels) or CT26-lpcat2 (right panels) tumours were subdivided into four groups (n = 8 per group) and treated as described in a. d Kaplan–Meier plots with time of death as endpoint for mice described in c are presented with p values assessed by the log-rank test
