Table 1 Mutations analyzed in this study

From: Probability of phenotypically detectable protein damage by ENU-induced mutations in the Mutagenetix database

Mutation classification

All mutations

Isolated mutations (>100 Mb from nearest neighbor)

Mutations from pedigrees with ≥3 G3 mice

Mutations in known essential genes

Probably benign (score ≤0.45)

26,004

2,406

2,311

477

Possibly damaging (score 0.45–0.95)

14,412

1,314

1,270

281

Probably damaging (score 0.95–1.0)

32,669

3,077

2,982

690

Probably null class I

5,170

462

441

78

Probably null class II

2,618

273

268

60

Total

80,873

7,532

7,272

1,586

  1. The columns represent progressive filtering steps from left to right
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