Fig. 10
From: Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology
Mislocalization of human pSer214 to spine. a Immunohistochemistry of pSer214-tau, which corresponds to mouse pSer203-tau, in human sporadic FTLD-TDP autopsy samples revealed similar mislocalization of specific types of tau to PSD95-positive spines (left images). Averages and s.e.m. are shown. Five independent cases were examined, and the averaged values of 10 visual fields (40 × 40 μm) in each case were used for quantitative analysis (right graphs). P-values were determined by Student’s t-test (N = 5). **p < 0.01. b Pathological diagnosis of patients was based on the presence of TDP43. Findings from each case are shown. p-values are shown in Supplementary data 1
