Fig. 3
From: Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis
Anatomical localization and proportions of fibroblast subsets. a Anatomical localization of fibroblast subsets and leukocytes in RA and OA synovial tissue. Hoechst 33258: white, CD45: cyan, PDPN: blue, CD34: green, THY1: red. Small arrowheads: CD34–THY1– fibroblasts. Big arrowheads: CD34–THY1+ fibroblasts. Arrows: CD34+ fibroblasts. Scale = 100 µm. b Expression of fibroblast subset markers in RA and OA synovial tissue. Hoechst 33258: white, CDH11: cyan, PDPN: blue, CD34: green, THY1: red. c Proportions of fibroblast subsets in synovial tissue in OA (n = 26) and RA (n = 16) evaluated by flow cytometry. P values from the Wilcoxon's rank-sum test. d Proportions of CDH11+ cells in CD34–THY1– fibroblasts, CD34–THY1+ fibroblasts, and CD34+ fibroblasts. L lining area, S sublining area
