Fig. 7
Features associated with negative and positive regulators underlying protein repression and RNA level predictions. a Partial dependence plots (PDPs) for selected features associated with a negative regulatory element depicting the contribution to the predicted protein repression and RNA level as a function of the ΔΔG. For each feature, a stronger interaction between the miRNA and the MRE is reflected in a lower ΔΔG. Boxplots (bottom) indicate the ΔΔG percentiles (5, 25, 50, 75, and 95) of the distribution of the ΔΔG values across all variants. Markers on the right end of each plot correspond to cases where the feature was not detected. Boxplots were calculated based on detected values only. b As in a, the PDPs for selected features corresponding to positive regulators. The hexamer sequence corresponding to each feature is indicated in each plot. c A table summarizing the number of features with a significant (FDR = 0.01) positive or negative Pearson correlation between the ΔΔG and either protein repression or RNA levels. Positive and negative regulatory effects are defined in the text. n.s. non-significant. d As in c following filtering of the features for a minimal partial dependence range of 0.05 for both protein repression and RNA level
