Fig. 9
From: Loss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration
MiR-128 deletion promotes adult cardiac regeneration after MI. a Representative images of Masson trichrome-stained heart section at 28 days after MI. Serial sectioning was performed at 500 µm intervals. The most significant difference between two groups is highlighted by the red box. Scale bars, 1 mm. b Measurement of fibrotic areas in heart sections following MI in control and iKO mice analyzed by Masson trichrome staining. (n = 8). c, d Heart function analyzed by echocardiography and quantified by LVDd, LVDs, EF, and FS (n = 6). Control (Ctrl) mice were miR-128fl/fl mice, iKO mice were α-MHCMerCreMer; miR-128fl/fl mice. Statistical significance was calculated using Student’s t-test in b, d. Data are represented as means ± SEM. *P < 0.05. NS, not significant
