Fig. 2

Normal T-cell development in naive CD11c-cre and LysM-cre K^b cKO mice. a Representative plots and b quantification show a block in thymocyte development only in CMV-cre K^b cKO animals, but not CD11c-cre K^b cKO animals (N = 7, 8, 5 per group, respectively). c Representative plots and d quantification show no disruption of thymocyte development in LysM-cre K^b cKO animals (N = 8 and 7 per group, respectively). e Representative plots and f quantification show abnormal splenic CD8⁺ T-cell proportions in naïve CMV-cre K^b cKO animals, but not CD11c-cre K^b cKO animals. g Representative plots and h quantification show normal splenic T-cell populations in naïve LysM-cre K^b cKO animals. Data presented as mean with error bars representing standard error of the mean (SEM). * denotes p < 0.05 by Mann−Whitney U Test or one-way ANOVA with Holm−Sidak correction