Fig. 4 | Nature Communications

Fig. 4

From: Non-equivalent antigen presenting capabilities of dendritic cells and macrophages in generating brain-infiltrating CD8+ T cell responses

Fig. 4

Dendritic cells and macrophages generate discrete CD8+ T-cell responses in cerebral malaria. a Timeline of infection and readout with Plasmodium berghei ANKA. b Representative flow plots and c−g quantification demonstrate a reduction proportion and number of brain-infiltrating CD8+ T cells, but not CD45hi immune cells or CD4+ T cells (N = 14, 3, 3, 5 per group, respectively). h No difference in proportion of parasitized red blood cells was found between cre-negative littermates and conditional knockout stains 6 days post infection (N = 10, 8, 10 per group, respectively). Data presented as mean with error bars representing standard error of the mean (SEM). * denotes p < 0.05 by Mann−Whitney U Test or one-way ANOVA with Holm−Sidak correction

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