Fig. 7

Dendritic cell-specific deletion of K^b disrupts CD8⁺ T-cell priming against gliomas. a Timeline of GL261-quad cassette tumor inoculation, bioluminescence imaging, and vaccination. b Representative flow cytometry plots. There was no difference in CD45^hi cell (c) or CD8⁺ T-cell (d) infiltration into the CNS of GL261-bearing animals. e Quantification demonstrate that CD11c-cre K^b cKO animals lose the ability to respond to GL261-gliomas following vaccination, though not as severely as CMV-cre K^b cKO animals (N = 5, 6, 6 per group, respectively). f Representative plots and g−i quantification demonstrate that LysM-cre K^b cKO animals respond to GL261-quad cassette gliomas similarly to controls (N = 10 per group). Data presented as mean with error bars representing standard error of the mean (SEM). * denotes p < 0.05 by Mann−Whitney U Test or one-way ANOVA with Holm−Sidak correction