Fig. 1

Identification of uc.372 upregulated in the livers of db/db mice and HFD-fed mice. a LncRNA-wide expression profiling in the liver of 8-week-old male db/db mice (n = 5). b Expression levels of ucRNAs in the liver of 8-week-old male db/db mice analyzed by real-time PCR (n = 5). c Expression levels of ucRNAs in the liver of 10-week-HFD-fed mice analyzed by real-time PCR (n = 5). d Distribution of uc.372 in various tissues of 6- to 8-week-old C57BL/6J mice (n = 3). e Distribution of uc.372 in various tissues of 10-week-HFD-fed mice (n = 5). f Expression level of uc.372 in HepG2 cells treated with 33.3 mM high glucose (HG), 20 nM tumor necrosis factor (TNF), 20 nM IL-6, or 300 μM O/P mixture (n = 3). Data are mean ± SEM; *P < 0.05; **P < 0.01; ***P < 0.001 vs. control group. (b, c, e Student’s t-test; d, f analysis of variance (ANOVA))