Fig. 4

HiCPlus can learn model from one cell type and predict in other cell types. Shown in the figures are real and HiCPlus-enhanced matrices in GM12878, K562 and IMR90 at 10 kb resolution. a HiCPlus-enhanced matrices in K562 with models trained in three different cell types are highly similar to each other, and all of them are also similar to the original K562 interaction matrix. b Model trained in GM12878 can be used to predict interaction matrices in different cell types (K562, GM12878 and IMR90). c High correlations between HiCPlus-enhanced matrices using models trained in three different cell types, 2D Gaussian kernel and high-resolution Hi-C at each genomic distance