Fig. 1

Synthesis and fabrication schematics of SCNPs for supramolecular theranostics. a Chemical structures and cartoon representations of the building blocks (β-CD-NH2, NHS-SS-NHS, cRGDfK-SH, and NHS-DOTA). b Synthetic route to the polyrotaxane (PDI-PCL-b-PEG-RGD⊃β-CD-NH2). c Schematic illustrations of the preparation of drug-loaded SCNPs and dual-responsive drug release