Table 1 ChA stability and affinity for CFH6/7
From: Structure-based design of chimeric antigens for multivalent protein vaccines
|  | Melting temperature (°C) | Affinity for CFH6/7 | |
|---|---|---|---|
Protein | N-terminal | C-Terminal | Kd (nM) |
fHbp V1.1 | 69.8 | 87.9 | 3.6 ± 0.4 |
fHbpV1.1:PorA151/P1.16 | 60.5 | 87.3 | 2.3 ± 0.2 |
fHbpV1.1:PorA267/P1.16 | 68.4 | 75.7 | 28 ± 3.0 |
fHbpV1.1:PorA294/P1.16 | 61.7 | 72.4 | 2.7 ± 0.4 |
fHbpV1.1:PorA117/P1.16 | 65.0 | 87.9 | 2.3 ± 0.8 |
fHbpV1.1:PorA183/P1.16 | 68.8 | 88.0 | NBD |
fHbpV1.1:PorA309/P1.16 | 69.0 | 76.9 | 5.5 ± 0.6 |
fHbp V1.4 | 64.4 | 89.4 | – |
fHbp V3.45 | 41.0 | 83.0 | – |
fHbpV1.4:PorA151/P1.1.10_1 | 54.0 | 89.0 | – |
fHbpV1.4:PorA151/P1.14 | 55.0 | 88.0 | – |
fHbpV1.4:PorA151/P1.15 | 55.0 | 89.0 | – |
fHbpV3.45:PorA158/P1.4 | 40.0 | 81.0 | – |
fHbpV3.45:PorA158/P1.9 | 39.0 | 80.0 | – |
