Fig. 2
From: Clonal dynamics towards the development of venetoclax resistance in chronic lymphocytic leukemia
Heterogeneous clonal evolutions under venetoclax therapy. Phylogenetic trees at the left side of each panel demonstrate the clonal evolution of the reconstructed cell populations for each patient. Highlighted mutations that occurred during tumor evolution are present in all descendent clones. Therefore, mutations in the most common ancestor population (C0) are present in all analyzed samples at a clonal level. The second type trees (right-bottom of each panel) demonstrate the phylogenetic relations of the matched pre-treatment and relapse samples from a patient, as commonly used in other cancer evolution studies10,13. Clonal composition of the samples (top-right of each panel) provides a link between both types of phylogenetic trees. We inferred diverse evolutionary paths across the patients: a linear evolution (C789), b branching evolution into three lineages (C577), c divergent evolution of two branches (C548), and d convergent evolution (C586). Pre-treatment sample names are displayed in red. Notable gene alterations are shown in the context of the ancestral relation of the clones
