Fig. 1
Sequence motifs and the structure of iPLA2β. a Domain composition of iPLA2β. ARs are shown in orange with the novel AR1 in dark orange, catalytic residues are in magenta, poly-Gly region is in green, and putative CaM-binding motifs in blue. Black lines underneath mark INAD and PD mutations. b Cartoon representation of the iPLA2β monomer color-coded in a rainbow scheme with the N terminus in blue and the C terminus in red. The catalytic dyad is shown by magenta spheres. The location of the unstructured loop between ANK and CAT domains is indicated by the dashed gray line and of the disordered membrane-interacting loop by the black dotted line. The position of the proline-rich insert in the long variant is shown by the grey arrow in this panel and by the red triangle in panel a
