Fig. 2

Configuration of the iPLA2β dimer in the crystal structure. a The CAT and ANK domains of a dimer are shown in cyan and light navy, respectively, in monomer A and in yellow and orange in monomer B. Putative CaM-binding 1-9-14 motifs in both monomers are shown in dark blue. Catalytic dyads are shown by magenta spheres. b Same dimer rotated by 90° around horizontal axis. The schematic drawing of a membrane illustrates the orientation of the membrane-binding surface of iPLA2β