Table 1 Allele frequencies for SNPs present on the genotyping array that exhibit a strong association with a phenotype (Phen-gen p-value < 10−8), and are in the 1q23 chromosomal region
SNP | Ref/alt | Associated phenotype | Observed frequency | Expected frequency (mean ± SD) | Probability of observed data | |||
|---|---|---|---|---|---|---|---|---|
Africa (%) | East Asia (%) | Madagascar (%) | ||||||
SD9 | rs1101999 | T/C | Asthma | 31 | 0 | 32 | 19 ± 1.9% | <10−6 |
rs3026968 | C/T | Chemokine CCL2 | 3 | 53 | 8 | 22 ± 2.1% | <10−6 | |
rs3093059 | A/G | C-reactive protein | 32 | 15 | 35 | 25 ± 2.2% | 2.10−5 | |
rs12075 | A/G | Leukocyte count | 2 | 92 | 7 | 37 ± 2.4% | <10−6 | |
SD6 | rs6684514 | G/A | Erythrocyte indices | 8 | 23 | 7 | 14 ± 1.7% | 4 × 10−6 |
rs1801274 | G/A | Mucocutaneous lymph node syndrome | 47 | 72 | 46 | 57 ± 2.5% | 1.4 × 10−5 | |
rs7528684 | G/A | Diabetes mellitus, type 1 | 6 | 56 | 11 | 25 ± 2.1% | <10−6 | |
rs1142287 | T/C | Crohn disease | 46 | 31 | 37 | 40 ± 2.5% | 9.55 × 10−2 | |
rs12566888 | T/G | Platelet aggregation | 35 | 51 | 36 | 41 ± 2.5% | 1.84 × 10−2 | |
rs13376333 | C/T | Atrial fibrillation | 30 | 3 | 23 | 20 ± 2.0% | 4.87 × 10−2 | |
