Fig. 4
From: Germinal center entry not selection of B cells is controlled by peptide-MHCII complex density
MHCII haploinsufficient GC B cells have robust competitive fitness in GCs. Kinetics of the proportion of MHCII+/+ cells and MHCII+/− cells within a total GC or b NP-binding GC B-cell compartments are shown. To normalize against B-cell chimerism variations in individual recipient animals, donor ratios in day 0 (unimmunized) splenic MF B cells were normalized to the donor ratios in BM LSK cells (MHCII+/+/MHCII+/−, black hollow circles; MHCII+/−/MHCII+/+, red hollow triangles). Donor ratios in the GC B cells (days 4–24 spleen and PPs) were normalized to the donor ratios in autologous MF B cells (MHCII+/+/MHCII+/−, black solid circles; MHCII+/−/MHCII+/+, red solid triangles). Data combined from three independent experiments (n = 3–15 for each time point or group); bars indicate mean values (±S.D.) of each group
