Table 1 List of 25 genome-wide significant SNPs in 23 loci that are associated with HR increase or HR recovery
CHR | SNPs | Position (hg19) | EA(Freq)/NEA | Beta | SE | p | Candidate gene | Primary Trait |
|---|---|---|---|---|---|---|---|---|
1 | rs11589125 | 31894396 | T(0.06)/C | 0.075 | 0.013 | 6.60 × 10−09 | SERINC2 n,c | HRR50 |
1 | rs272564 | 45012273 | A(0.71)/C | 0.046 | 0.007 | 1.40 × 10−12 | RNF220 n,h | HRR50 |
1 | rs61765646 | 72723211 | A(0.19)/T | 0.056 | 0.008 | 1.10 × 10−13 | NEGR1 n | HRR10 |
2 | rs1899492 | 60000304 | T(0.47)/C | 0.040 | 0.006 | 1.70 × 10−11 | Gene desert | HRR40 |
2 | rs17362588 | 179721046 | G(0.92)/A | 0.062 | 0.011 | 3.10 × 10−09 | CCDC141n,c,TTNh | HRR10 |
2 | rs35596070 | 179759692 | C(0.86)/A | 0.060 | 0.008 | 4.20 × 10−13 | CCDC141n,c,TTNh | HRR10 |
3 | rs73043051 | 18883863 | C(0.22)/T | 0.041 | 0.007 | 7.80 × 10−09 | KCNH8 n | HRR50 |
3 | rs34310778 | 74783408 | C(0.43)/T | 0.036 | 0.006 | 1.00 × 10−09 | CNTN3 n,e | HRR30 |
5 | rs4836027 | 121866990 | T(0.68)/C | 0.050 | 0.006 | 1.70 × 10−15 | SNCAIPn,PRDM6n,h | HRinc |
5 | rs151283 | 122446619 | C(0.72)/A | 0.042 | 0.007 | 1.60 × 10−10 | PRDM6 nh | HRR50 |
6 | rs2224202 | 102053814 | A(0.19)/G | 0.043 | 0.007 | 5.80 × 10−09 | GRIK2 n,h | HRR20 |
7 | rs2158712 | 26582733 | A(0.52)/T | 0.045 | 0.006 | 2.80 × 10−13 | SKAP n,h | HRR10 |
7 | rs180238 | 93550447 | T(0.65)/C | 0.043 | 0.006 | 2.20 × 10−12 | GNG11n,GNGT1n,e,TFPI2n,e | HRR40 |
7 | rs3757868 | 100482720 | G(0.82)/A | 0.077 | 0.008 | 5.60 × 10−24 | SRRTn,e,ACHEn,e,TRIP6e,C7orf43n,e,UFSP1n | HRR40 |
7 | rs1997571 | 116198621 | A(0.58)/G | 0.042 | 0.006 | 1.70 × 10−12 | CAV1n,h,CAV2n,e,h | HRR20 |
7 | rs17168815 | 136624621 | G(0.84)/T | 0.062 | 0.008 | 1.10 × 10−14 | CHRM2 n | HRR50 |
10 | rs7072737 | 102556175 | A(0.11)/G | 0.079 | 0.009 | 1.10 × 10−17 | PAX2 n | HRR40 |
11 | rs7130652 | 71984398 | T(0.07)/G | 0.076 | 0.011 | 3.40 × 10−11 | CLPBn,h,INPPL1n,e | HRR10 |
12 | rs4963772 | 24758480 | A(0.15)/G | 0.090 | 0.008 | 1.20 × 10−28 | BCAT1 n | HRR40 |
12 | rs6488162 | 33593127 | C(0.58)/T | 0.103 | 0.006 | 2.60 × 10−66 | SYT10n,ALG10h | HRR10 |
12 | rs61928421 | 116227249 | C(0.93)/T | 0.090 | 0.012 | 4.30 × 10−15 | MED13L n | HRR40 |
14 | rs17180489 | 72885471 | C(0.14)/G | 0.055 | 0.008 | 2.50 × 10−11 | RGS6 n,h | HRinc |
15 | rs12906962 | 95312071 | T(0.67)/C | 0.048 | 0.006 | 2.70 × 10−14 | MCTP2 n | HRinc |
19 | rs12974440 | 5894386 | G(0.92)/A | 0.067 | 0.011 | 2.40 × 10−10 | FUT5n, NDUFA11n,c | HRR10 |
19 | rs12986417 | 30109533 | G(0.65)/A | 0.037 | 0.006 | 1.00 × 10−09 | POP4n,C19orf12h | HRinc |
