Fig. 6
From: The choroid plexus is an important circadian clock component
a Targeted deletion of Bmal1 in the CP lengthens the behavioral circadian period. Two representative double-plotted circadian actograms in mice that lack Bmal1 in the CP. b Two representative double-plotted actograms in congenic controls. c In mice with CP-targeted Bmal1 deletion, the circadian locomotor period becomes significantly longer than the control, which is the same as the wild type C57BL/6J (23.7 h) (homozygous knockdown (Homo., n = 4; open squares) against control (CTRL, n = 4; open circles): **p < 0.01; heterozygous knockdown (Het., n = 5; open diamonds) against control (CTRL): #p = 0.066, Welch’s t-test). d A hypothetical diagram for connection between the CP and the SCN. The CP is likely to tune the SCN through the CSF, while the SCN relays the light signal to the CP by a non-CSF-mediated pathway. e In the SCN, expression of the Bmal1 transcript is unaffected by the CP-specific Cre recombinase FOXJ1-Cre and is independent of the behavioral locomotor period. In both 4V CP and LV CP, Bmal1 expression is close to null in the animals expressing FOXJ1-Cre. In control littermates, Bmal1 expression varied, but was higher than zero. This makes an inverse correlation between Bmal1 expression and the locomotor period (Pearson’s correlation coefficient). Open squares, diamonds, circles indicate samples from the same animals in c
