Fig. 1

Structure of rSLFN13 N′-domain. a Schematic representation showing the organisation of crystallised rSLFN13_14–353 based on full-length rSLFN13. NE denotes the N-terminal extension coded by the DNA sequence from the vector; BD denotes bridging domain. Elements for rSLFN13_14–353 are assigned according to the structure. Borders of each element are indicated by residue numbers. b Structure of rSLFN13_14–353. Domains of rSLFN13_14–353 are indicated and coloured as in a. Disordered loops are shown as dashed lines. The Zn²⁺ ion in the zinc finger is shown as a grey sphere. α-helices and β-strands of each domain are specified. The size of the valley is indicated. c The topology diagram of rSLFN13_14–353. Secondary structural elements were not drawn to scale. Elements of rSLFN13_14–353 are named and coloured as in a. A dashed line is drawn to indicate the pseudo-symmetry of rSLFN13_14–353. d Interactions between BD and N-lobe. Side chains of involved residues are shown in the same colour as the domains they belong to. e Interactions between BD and C-lobe. Note the similarity with d. f Extra interactions between BD and C-lobe. Note the CCCH-type zinc finger