Table 1 Thirteen representative eGenes (9 most significant genes and 4 GWAS loci) that correlate with BMI in METSIM and TwinsUK (for the full data on all 54 genes, see Supplementary Table 6)
Pearson | Linear regression | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Ranka | Gene | Chrf | METSIMc | METSIMd | TwinsUKe | |||||
Effect size (r) | p-value | Effect size (β) | SE | p-value | Effect size (β) | SE | p-value | |||
1 | ADH1B | 4 | −0.45 | 7.40 × 10−18 | −0.21 | 0.02 | 1.68 × 10−20 | −0.58 | 0.03 | 4.47 × 10−71 |
2 | ORMDL3 b | 17 | −0.45 | 8.57 × 10−18 | −0.16 | 0.02 | 2.06 × 10−20 | −0.58 | 0.03 | 2.65 × 10−70 |
3 | AKR1C3 | 10 | 0.33 | 4.78 × 10−10 | 0.13 | 0.02 | 2.95 × 10−11 | 0.49 | 0.03 | 5.19 × 10−54 |
4 | CMTM3 | 16 | 0.41 | 4.32 × 10−15 | 0.087 | 0.01 | 3.84 × 10−17 | 0.50 | 0.03 | 6.64 × 10−52 |
5 | LPIN1 | 2 | −0.38 | 1.49 × 10−13 | −0.14 | 0.02 | 2.27 × 10−15 | −0.47 | 0.03 | 2.38 × 10−44 |
6 | RNF157 | 17 | −0.29 | 5.19 × 10−8 | −0.096 | 0.02 | 5.87 × 10−9 | −0.47 | 0.03 | 8.86 × 10−42 |
7 | MYOF | 10 | 0.32 | 1.07 × 10−9 | 0.086 | 0.01 | 7.37 × 10−11 | 0.46 | 0.03 | 2.59 × 10−40 |
8 | NAA40 | 11 | 0.28 | 1.81 × 10−7 | 0.052 | 0.009 | 2.67 × 10−8 | 0.46 | 0.03 | 4.00 × 10−40 |
9 | TMEM165 | 4 | 0.33 | 2.45 × 10−9 | 0.045 | 0.007 | 1.84 × 10−10 | 0.45 | 0.03 | 3.52 × 10−37 |
10 | RFFL | 11 | 0.27 | 1.02 × 10−6 | 0.035 | 0.006 | 1.84 × 10−7 | 0.43 | 0.03 | 5.67 × 10−37 |
28 | ACADS b | 12 | −0.37 | 2.91 × 10−12 | −0.085 | 0.01 | 7.12 × 10−14 | −0.24 | 0.03 | 6.65 × 10−19 |
31 | LACTB b | 15 | 0.30 | 1.67 × 10−8 | 0.069 | 0.01 | 1.40 × 10−9 | 0.32 | 0.04 | 4.94 × 10−18 |
34 | MAP2K5 b | 15 | −0.25 | 7.83 × 10−6 | −0.039 | 0.01 | 1.90 × 10−6 | −0.21 | 0.03 | 3.81 × 10−10 |
