Fig. 1
From: Estrogen receptor α drives pro-resilient transcription in mouse models of depression
ERα is a predicted upstream regulator of pro-resilient transcriptional changes in NAc. a Experimental overview of upstream regulator analysis. NAc genes differentially expressed in control, CSDS susceptible, and CSDS resilient mice 48 h post defeat were used to predict upstream regulators. b Findings from IPA upstream regulator analysis on differentially expressed genes in CSDS. ESR1, which encodes ERα, is the top-predicted upstream regulator of differentially expressed genes (log fold change >1; P < 0.05) in the resilient vs. control (predicted activation; z-score = 3.16; P < 6.64 × 10−6) and susceptible vs. resilient (predicted inhibition; z-score = 3.22; P < 1.38 × 10−8) comparisons, with no predicted upstream regulator activity in susceptible vs. control. c Known interactions of differentially expressed genes (log fold change > 1) in the resilient vs. control and susceptible vs. resilient comparisons giving rise to the prediction of ESR1 as an upstream regulator
