Table 2 Results from cross-ancestry meta-analysis (chromosomes 8–22)
SNP | Chr:bp | Nearest gene | A1/A2 | European-specific meta-analysis | Asian-specific meta-analysis | Cross-ancestry meta-analysis | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
A1F | β (SE) | P | A1F | β (SE) | P | A1F | β (SE) | P | N | ||||
rs3808520 | 8:23164773 | LOXL2 | c/g | 0.21 | 2.50 (0.48) | 2.61E-07 | 0.10 | 2.02 (0.88) | 2.28E-02 | 0.18 | 2.39 (0.42) | 2.02E-08 | 24,899 |
rs10429294 | 8:95969322 | NDUFAF6 | t/c | 0.50 | 2.36 (0.39) | 2.21E-09 | 0.66 | 1.34 (0.55) | 1.60E-02 | 0.56 | 2.02 (0.32) | 3.48E-10 | 24,899 |
rs7026684 | 9:4215308 | GLIS3 | a/g | 0.36 | −2.00 (0.39) | 4.24E-07 | 0.39 | −1.81 (0.55) | 1.04E-03 | 0.37 | −1.94 (0.32) | 1.73E-09 | 25,910 |
rs66720556 | 9:13559717 | MPDZ | a/t | 0.18 | −1.86 (0.51) | 3.01E-04 | 0.25 | −3.80 (0.59) | 2.18E-10 | 0.21 | −2.68 (0.39) | 6.06E-12 | 24,071 |
rs10980623 | 9:113660537 | LPAR1 | a/g | 0.79 | −2.63 (0.46) | 1.06E-08 | 0.79 | −3.43 (0.63) | 6.06E-08 | 0.79 | −2.90 (0.37) | 5.63E-15 | 25,910 |
rs3132303 | 9:137444298 | COL5A1 | c/g | 0.26 | 5.23 (0.49) | 6.11E-26 | 0.26 | 5.91 (0.71) | 1.21E-16 | 0.26 | 5.45 (0.40) | 8.35E-41 | 24,899 |
rs7040970 | 9:139859013 | LCN12 | t/c | 0.49 | 3.35 (0.41) | 3.54E-16 | 0.72 | 1.80 (0.63) | 4.31E-03 | 0.56 | 2.89 (0.34) | 4.75E-17 | 24,899 |
rs35809595 | 10:63831928 | ARID5B | a/g | 0.40 | −2.29 (0.39) | 8.97E-09 | 0.36 | −2.66 (0.53) | 6.56E-07 | 0.39 | −2.43 (0.32) | 3.40E-14 | 24,899 |
rs2419835 | 10:115296564 | HABP2 | t/c | 0.86 | 2.21 (0.54) | 4.70E-05 | 0.45 | 2.33 (0.52) | 9.01E-06 | 0.65 | 2.27 (0.37) | 1.74E-09 | 25,910 |
rs4938174 | 11:110913240 | ARHGAP20-C11orf53 | a/g | 0.30 | 1.82 (0.41) | 9.97E-06 | 0.15 | 3.74 (0.75) | 6.14E-07 | 0.26 | 2.26 (0.36) | 3.59E-10 | 25,910 |
rs56009602 | 11:130289612 | ADAMTS8 | t/c | 0.05 | 6.86 (0.92) | 1.30E-13 | 0.10 | 7.24 (0.93) | 1.25E-14 | 0.08 | 7.05 (0.66) | 1.16E-26 | 25,910 |
rs7308752 | 12:91527181 | DCN | a/g | 0.91 | 3.87 (0.67) | 1.07E-08 | 0.73 | 2.28 (0.68) | 7.91E-04 | 0.82 | 3.08 (0.48) | 1.34E-10 | 25,302 |
rs11553764 | 12:104415244 | GLT8D2 | t/c | 0.17 | 3.19 (0.53) | 2.77E-09 | 0.20 | 4.14 (0.67) | 8.62E-10 | 0.18 | 3.55 (0.42) | 2.47E-17 | 24,899 |
rs10161679 | 13:23243645 | FGF9-SGCG a | a/g | 0.71 | −2.40 (0.45) | 1.41E-07 | 0.72 | −1.99 (0.64) | 2.16E-03 | 0.71 | −2.26 (0.37) | 1.28E-09 | 24,899 |
13:41112152 | 13:41112152 | FOXO1 | i/r | 0.10 | −5.44 (0.66) | 2.15E-16 | 0.03 | −2.52 (1.81) | 1.64E-01 | 0.10 | −5.10 (0.62) | 2.54E-16 | 24,071 |
rs56223983 | 14:81814754 | STON2 | t/g | 0.30 | 2.01 (0.42) | 1.83E-06 | 0.30 | 1.99 (0.58) | 5.94E-04 | 0.30 | 2.00 (0.34) | 4.14E-09 | 25,910 |
rs785422 | 15:30173885 | TJP1 | t/c | 0.11 | −4.01 (0.63) | 2.65E-10 | 0.08 | −3.50 (1.26) | 5.75E-03 | 0.10 | −3.91 (0.56) | 5.72E-12 | 21,810 |
rs8030753 | 15:48801935 | FBN1 | t/c | 0.13 | 2.02 (0.55) | 2.75E-04 | 0.27 | 2.51 (0.59) | 2.29E-05 | 0.20 | 2.25 (0.40) | 2.87E-08 | 25,910 |
rs12912010 | 15:67467143 | SMAD3 | t/g | 0.22 | 2.76 (0.47) | 6.40E-09 | 0.36 | 2.21 (0.53) | 3.92E-05 | 0.28 | 2.52 (0.35) | 1.50E-12 | 24,899 |
rs4843040 | 15:85838636 | AKAP13 b | t/c | 0.24 | −2.92 (0.44) | 3.62E-11 | 0.47 | −2.35 (0.52) | 6.68E-06 | 0.33 | −2.68 (0.33) | 1.68E-15 | 25,910 |
rs930847 | 15:101558562 | LRRK1 | t/g | 0.77 | −3.57 (0.45) | 3.19E-15 | 0.73 | −3.79 (0.61) | 7.82E-10 | 0.76 | −3.64 (0.36) | 1.63E-23 | 25,910 |
rs35193497 | 16:88324821 | ZNF469 | t/g | 0.36 | −6.23 (0.43) | 8.64E-47 | 0.29 | −4.92 (0.62) | 2.34E-15 | 0.34 | −5.80 (0.35) | 8.08E-60 | 24,899 |
rs4792535 | 17:14565130 | HS3ST3B1 | t/c | 0.29 | −2.43 (0.41) | 3.61E-09 | 0.47 | −2.04 (0.54) | 1.72E-04 | 0.36 | −2.29 (0.32) | 3.13E-12 | 25,302 |
rs8133436 | 21:47519535 | COL6A2 | t/c | 0.05 | 3.90 (1.07) | 2.84E-04 | 0.25 | 3.47 (0.72) | 1.85E-06 | 0.18 | 3.61 (0.60) | 2.17E-09 | 24,899 |
rs71313931 | 22:19960184 | ARVCF | c/g | 0.71 | −2.23 (0.44) | 5.49E-07 | 0.78 | −2.22 (0.70) | 1.59E-03 | 0.73 | −2.23 (0.37) | 3.21E-09 | 24,071 |
